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Nihilistic anxiety is also called existential angst.
Nihilistic anxiety is pervasive; it is not about anything in particular.
Not being able to make sense of specific things naturally causes anxiety about them, because of uncertainty. Not being able to make sense of anything—a consequence of nihilism—causes non-specific, pervasive anxiety.
The underlying worry is that our perception of meaningness is unreliable. Therefore, there is no sensible way to choose activities. Paralysis results. Anxiety alienates one from all projects, and from social involvement. This is depressing.
“Cosmic horror” fiction—such as Lovecraft’s Cthulhu stories—express nihilistic anxiety. They convey the feeling that everything is horrible and doomed, without making any actual sense. As I’ve written elsewhere, this is silly (although fun if you don’t take them seriously).
Actually, in nihilistic anxiety and depression, everything shows up as existent but meaningless, and therefore silly. This includes oneself. In existentialism, this is called “The Absurd.”
Perceiving this absurdity is valuable, because it’s funny—or can be. Laughter is enjoyable, which points to a route out of nihilism.